So, this is a new one: when trying to start my freshly compiled MAME 0.216 using Xcode 11.2.1 under Catalina, I'm getting the following error:
zsh: exec format error: ./MAME
I did not observe anything special during compilation (but I did not pay special attention either).
I had no problems using the previous version on macOS 10.15 (using the same version of Xcode, maybe 0.1 version earlier).