Nope, none of those settings have any effect. I played with every timing related setting in Nestopia. If I set the framerate to 59 in Nestopia, it almost works, but there is tearing and the game is not technically running at full speed. Setting vsync in the nvidia control panel is the only way to correct the problem. Not an issue on ati cards. I can get around the issue by creating a game profile around nestopia.exe in the control panel and enforcing vsync as the option, but I thought Marty should be aware of the issue.