This may be just my PC, but whenever I use a USB device in Nestopia (a brilliant emulator!), I get a fraction of a second delay on button presses. I have a wireless keyboard and a wired Logitech USB gamepad.
When I switch to a PS/2 keyboard (no reboot, both keyboards are plugged in- this is a HTPC) there is no lag; response is terrific!
I was hoping someone had the same experience and knew a quick fix. I've updated my system bios (Dell 8400), Intel chipset drivers (including USB), went through all the emulator options that I thought would affect it, but the lag remains.
Thanks for a great emulator!