I finished playing through the Policenauts English translation
. The only potential problem is that when there is a long voice over audio type of thing, it'll crack a bit and then stop playing. I haven't yet confirmed this on real hardware, but intend to. (It can be replicated by watching the Intro movie when playing a new game... the sound stops when Jonathan Ingram is doing his EVA.)
Even 19 years later, this game was really fun!
In case you weren't aware, the credits inform you that Hideo Kojima was associated with this game.
I just found out that Policenauts supports the Playstation mouse. I guess support for that could be added as a slot device! ( details about psx mouse (search for "psx mouse")