I see it. I figured it was something like that.
http://git.redump.net/cgit.cgi/mess/tree/src/mess/layout/px4.lay
Edit values as desired and recompile.

I need to ask Mr. Do about how layouts take precedence over each other. Assuming they can, you could place an "INVERT" layout per LCD system in the layout folder, or a layout which makes the LCD per monochrome black-on-white. If they can't, then you remove the precompiled layout from the source and add one after the fact.

Still curious about whether all monochrome/greyscale LCD handheld systems have layouts that determine the coloring, or if some still need made.

- Stiletto