For Megadrive, the fixed lists will actually make it harder though. Right now you simply point it to the specific ROM file you want to play, whereas with the lists you have to have them in the specific folder. Existing MAME users will understand that concept, but a lot of noobs actually give up on MAME because they don't.
I think there are enough 'existing MAME users' for the concept to be well understood, and for people to get help when they don't understand it. Besides, the old mechanism will still exist, but anybody wanting to report bugs will be expected to use the fixed lists and proper setnames I'm guessing. (or at least that would be my requirement for taking any bug reports given the number of times the problem has come down to 'bad rom' when people have reported things to me in the past)