For those who use MESSUI, i've added a per-game property sheet containing the more important HLSL sliders, plus a on/off switch. The page will be greyed out if you are not running D3D version 9. Also, if you turn on HLSL, you need to hit Apply before the sliders become available. (This is the same way the rest of messui works).
If your system is set up properly, the settings will be saved into the game's ini file. The Reset and Restore Defaults buttons don't do anything at the moment, so if you manage to totally screw up, delete your ini file and start over.